T7947

(R)-Tomoxetin -hydrochlorid

solid

• Synonym(e): (R)-N-Methyl-γ-(2-methyl­phenoxy)-benzolpropanamin -hydrochlorid
• Empirische Formel (Hill-System): C₁₇H₂₁NO · HCl
• CAS-Nummer: 82248-59-7
• Molekulargewicht: 291.82
• NACRES: NA.77
• PubChem Substance ID: 24278760
• UNSPSC Code: 12352200
• MDL number: MFCD06410992
• Form: solid

Eigenschaften

• form: solid
• Quality Segment: 100
• originator: Eli Lilly
• storage temp.: 2-8°C
• SMILES string: CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
• InChI: 1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
• InChI key: LUCXVPAZUDVVBT-UNTBIKODSA-N
• Gene Information: human ... SLC6A2(6530)

Beschreibung

Application

(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:

• to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice[1]
• to study its effects on set shifting in rats[2]
• to study its effects on rat brain as a result of its long-term use[3]

Biochem/physiol Actions

(R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters.[4] It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC).[2] (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter.[2] It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.[2]. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).[4]

Norepinephrine uptake blocker.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)