T4949

Taprostene sodium salt

≥98% (HPLC)

• Synonym(e): Rheocyclan, Sodium 3-[(Z)-[(3aR,4R,5R,6aS)-4-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]benzoate
• Empirische Formel (Hill-System): C₂₄H₂₉NaO₅
• CAS-Nummer: 87440-45-7
• Molekulargewicht: 420.47
• NACRES: NA.77
• PubChem Substance ID: 24724631
• UNSPSC Code: 12352202
• MDL number: MFCD05664743
• Assay: ≥98% (HPLC)

Eigenschaften

• assay: ≥98% (HPLC)
• color: off-white
• mp: 173-182.5 °C (lit.)
• solubility: H₂O: 26 mg/mL
• storage temp.: 2-8°C
• SMILES string: [Na+].[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C3CCCCC3)[C@@]1([H])C\C(O2)=C\c4cccc(c4)C([O-])=O
• InChI: 1S/C24H30O5.Na/c25-21(16-6-2-1-3-7-16)10-9-19-20-13-18(29-23(20)14-22(19)26)12-15-5-4-8-17(11-15)24(27)28;/h4-5,8-12,16,19-23,25-26H,1-3,6-7,13-14H2,(H,27,28);/q;+1/p-1/b10-9+,18-12-;/t19-,20-,21-,22-,23+;/m1./s1
• InChI key: KPQVOJYDUCZQEQ-REHYUDDHSA-M

Beschreibung

Application

Taprostene has been used as an IP receptor agonist and was found to increase cAMP expression in human bronchial epithelial cells¹.

Biochem/physiol Actions

Highly selective IP₁ prostanoid receptor agonist.

Preparation Note

Taprostene is soluble in water at 26 mg/ml.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves