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T0826
TBB
≥98% (HPLC), solid
Synonym(e):
4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634, TBBt
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 10 mg | Warenkorb auf Verfügbarkeit prüfen | € 272,00 € 231,20 |
Über diesen Artikel
Empirische Formel (Hill-System):
C6HN3Br4
CAS-Nummer:
Molekulargewicht:
434.71
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
€ 231,20
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Unterstützung erhaltenQuality Level
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: 28 mg/mL
storage temp.
2-8°C
SMILES string
Brc1c(Br)c(Br)c2[nH]nnc2c1Br
InChI
1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
InChI key
OMZYUVOATZSGJY-UHFFFAOYSA-N
Application
TBB was used to study casein kinase 2-dependent phosphorylation of DNA damage mediator protein MDC1.[1]
Biochem/physiol Actions
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP.[2] TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.[3]
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 mM, using rat liver and recombinant human CK2, respectively).
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Dieser Artikel | |||
|---|---|---|---|
| form solid | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 28 mg/mL | solubility DMSO: >10 mg/mL at 60 °C, clear | solubility DMSO: 2 mg/mL, clear | solubility - |
| color white | color - | color white to beige | color white to beige |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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S Sarno et al.
FEBS letters, 496(1), 44-48 (2001-05-10)
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2), has been examined against a panel of 33 protein kinases, either Ser/Thr- or Tyr-specific. In the presence of 10 microM TBB (and 100 microM ATP)
J Ross Chapman et al.
EMBO reports, 9(8), 795-801 (2008-06-28)
Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such sites. Central to these DNA damage response (DDR) events is the DNA damage mediator protein MDC1. MDC1 interacts with several DDR proteins
Maria Ruzzene et al.
The Biochemical journal, 364(Pt 1), 41-47 (2002-05-04)
Incubation of Jurkat cells with 4,5,6,7-tetrabromobenzotriazole (TBB), a specific inhibitor of protein kinase CK2, induces dose-and time-dependent apoptosis as judged by several criteria. TBB-promoted apoptosis is preceded by inhibition of Ser/Thr phosphorylation of haematopoietic lineage cell-specific protein 1 (HS1) and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T0826-10MG | 04061837335822 |