SRP8057

Tim-4 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• Synonym(e): T-cell membrane protein 4, TIM4, TIMD4
• NACRES: NA.32
• UNSPSC Code: 12352200
• Form: lyophilized
• Assay: ≥98% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in CHO cells
• Mol wt: monomer 58 kDa by calculation

Eigenschaften

• biological source: human
• recombinant: expressed in CHO cells
• assay: ≥98% (SDS-PAGE)
• form: lyophilized
• mol wt: monomer 58 kDa by calculation
• packaging: pkg of 100 μg
• impurities: <0.06 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: Q96H15
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... TIMD4(91937)

Beschreibung

General description

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.

Physical form

Lyophilized from 0.2 μm-filtered solution in PBS.

Preparation Note

Reconstitute at 100 μg/mL in sterile PBS.

Other Notes

The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of human IgG1.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable