SRP8040

LAG-3 (human): FC (human)

recombinant, expressed in CHO cells, >99% (SDS-PAGE)

• Synonym(e): FDC Protein, Lymphocyte activation gene-3, PC cell-derived growth factor
• NACRES: NA.32
• UNSPSC Code: 12352200
• Form: liquid
• Assay: >99% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in CHO cells
• Mol wt: ~80 kDa by SDS-PAGE

Eigenschaften

• biological source: human
• recombinant: expressed in CHO cells
• assay: >99% (SDS-PAGE)
• form: liquid
• mol wt: ~80 kDa by SDS-PAGE
• packaging: pkg of 50 μg
• concentration: ≥0.2 mg/mL
• impurities: <0.1 EU/μg endotoxin, tested
• color: clear
• UniProt accession no.: P18627
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... LAG3(3902)

Beschreibung

General description

LAG3 (lymphocyte activation gene 3) is an inhibitory CD4 (cluster of differentiation)-related molecule, and is expressed by activated CD4⁺ and CD8⁺ T cells.[1]

Biochem/physiol Actions

LAG3 (lymphocyte activation gene 3) is a negative regulator of T-cell proliferation where it suppresses T-cell receptor (TCR)-mediated calcium fluxes and modulates the memory T-cell pool size. It is a CD4 (cluster of differentiation) homolog that functions as a ligand for MHC (major histocompatibility complex) II. Membrane expression of LAG3 modulates the suppressive function of Tregs (T-regulatory) both in vivo and in vitro.[1] HIV-1 (human immunodeficiency virus) infection results in significant increase in LAG3 peripheral blood and lymph node expression, which is exhibited on both CD4⁺ and CD8⁺ T cells, and this is linked with disease progression.[2] In melanoma, this protein is responsible for TLR (Toll-like receptor)-independent activation of plasmacytoid dendritic cells (pDCs) at tumor sites, which is partially implicated in driving an immune-suppressive environment.[3]

Physical form

Solution in PBS.

Other Notes

The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 1