SRP2075

SRC1, FLAG tagged, TEV site human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Synonym(e): F-SRC-1, KAT13A, MGC129719, MGC129720, RIP160, SRC1, bHLHe42, bHLHe74
• NACRES: NA.26
• UNSPSC Code: 12352200
• Assay: ≥80% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in E. coli
• Concentration: 1000 μg/mL

Eigenschaften

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥80% (SDS-PAGE)
• form: frozen liquid
• mol wt: ~19.5 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• concentration: 1000 μg/mL
• color: clear colorless
• NCBI accession no.: NM_003743
• UniProt accession no.: Q15788
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... NCOA1(8648)

Beschreibung

Biochem/physiol Actions

Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 has been shown to be over expressed in some cancers. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptorsand have been previously used in assays detecting ligand-dependent receptor-cofactor interactions. This protein contains the Tobacco Etch virus (TEV) protease site and can be cleaved using acTEV to yield untagged SRC1 RID. This protein will be useful for assays where a native untagged protein is desired.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable