This product is not full length. It contains amino acids 1-212 and includes a C-terminal His tag.
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SRP0187
Bcl-xL Active human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(e):
Apoptosis regulator Bcl-X, BCL-XL/S, BCL2L1, Bcl-2-like protein 1
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 100 μg | Versand in der Regel in 2 Wochen. | € 638,00 |
Über diesen Artikel
NACRES:
NA.32
UNSPSC Code:
12352200
Technischer Dienst
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Unterstützung erhaltenbiological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
aqueous solution
mol wt
28 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
>0.02 mg/mL
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... BCL2L1(598)
General description
BCL2L1 (B-cell lymphoma 2 like 1) gene codes for the anti-apoptotic protein called Bcl-xL (B-cell lymphoma-extra large) and its isoform Bcl-xS. Bcl-xS functions as an antagonist of Bcl-xL. This gene is localized to human chromosome 20q11.21.
Application
Useful for the study of apoptosis, screening inhibitors, and selectivity profiling.
Biochem/physiol Actions
BCL2L1 (B-cell lymphoma 2 like 1) or Bcl-xS functions as a dominant negative regulator of the anti-apoptotic isoform Bcl-xL. Bcl-xL is involved in modulating anti-apoptotic capacity of chemotherapy-resistant tumors. This protein is highly expressed in michigan cancer foundation 7 (MCF7) human breast carcinoma cells, and studies show that overexpression of Bcl-xS in these MCF-7 cells results in heightened sensitivity to chemotherapy-induced apoptosis by agents such as VP-16 or taxol.
Physical form
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT.
Preparation Note
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
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Dieser Artikel | |||
|---|---|---|---|
| biological source human | biological source rabbit | biological source human | biological source rat |
| assay ≥90% (SDS-PAGE) | assay - | assay ≥80% (SDS-PAGE) | assay - |
| recombinant expressed in E. coli | recombinant - | recombinant expressed in E. coli | recombinant - |
| form aqueous solution | form - | form aqueous solution | form - |
| storage condition avoid repeated freeze/thaw cycles | storage condition - | storage condition avoid repeated freeze/thaw cycles | storage condition - |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in wet ice |
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
Zulassungslistungen
Zulassungslistungen werden hauptsächlich für chemische Produkte erstellt. Für nicht-chemische Produkte können hier nur begrenzte Angaben gemacht werden. Kein Eintrag bedeutet, dass keine der Komponenten gelistet ist. Es liegt in der Verantwortung des Benutzers, die sichere und legale Verwendung des Produkts zu gewährleisten.
288-32-4
CAS No.
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Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis.
Sumantran VN, et al.
Cancer Research, 55(12), 2507-2510 (1995)
Francis McCoy et al.
Methods in molecular biology (Clifton, N.J.), 1133, 119-140 (2014-02-26)
The study of apoptosis and caspases has advanced greatly over recent decades. Studies conducted in the Xenopus laevis egg extract and oocyte model system have significantly contributed to these advances. Twenty years ago, Newmeyer and colleagues first showed that the
Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation.
Keitel U, et al.
Oncotarget, 5(23), 11778-11791 (2014)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP0187-100UG | 04061837112034 |
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Is the BCl-xl full length(233 aa)? or the C-terminal is excluded
1 answer-
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