SML3478

PNU-159682

≥95% (HPLC)

• Synonym(e): (8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[(1S,3R,4aS,9S,9aR,10aS)-octahydro-9-methoxy-1-methyl-1H-pyrano[4′,3′:4,5]oxazolo[2,3-c][1,4]oxazin-3-yl]oxy]-5,12-naphthacenedione, PNU 159682
• Empirische Formel (Hill-System): C₃₂H₃₅NO₁₃
• CAS-Nummer: 202350-68-3
• Molekulargewicht: 641.62
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD12756329
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: under inert gas

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: under inert gas
• color: , Faint red to very dark red
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Highly potent anthracycline toxin

PNU-159682, an active nemorubicin metabolite, is a highly potent anthracycline toxin that retains antitumor activity in vivo. Similarly to other anthracyclines PNU-159682 intercalates between the CG base pairs of DNA, but the stability of the complexes is much higher.

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H341,H351,H360FD
• pcodes: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable