SML3222

TM-N1324

≥98% (HPLC)

• Synonym(e): 4-(2-Chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one
• Empirische Formel (Hill-System): C₁₈H₁₃ClFN₇O
• CAS-Nummer: 1144477-35-9
• Molekulargewicht: 397.79
• UNSPSC Code: 12352107
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=NN(C(N2)=C1C(C3=C(Cl)C=C(F)C=C3)CC2=O)C4=NC=NC5=C4NC=N5
• InChI key: CYQNVXRIWKKWQG-UHFFFAOYSA-N

Beschreibung

General description

TM-N1324 also known as Cpd1324[1] is an agonist of GPR39, a G-protein-coupled receptor activated by Zn2+. GPR39 is a member of the ghrelin receptor family that has been implicated in the control of glucose-induced insulin secretion, pancreatic β-cell differentiation, control of lipolysis in white adipose tissue, and may also be involved in the pathophysiology of depression. TM-N1324 is found to activate human GPR39 with potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively, and murine GPR39 with potencies of 180 nM and 5 nM in the absence and presence of Zn2+. TM-N1324 is known to stimulate gastric somatostatin secretion, indirectly inhibiting ghrelin secretion. It shows no agonist activity for 156 other GPCRs tested or for related receptors ghrelin and motilin. TM-N1324 serves as a tool to explore the physiological function of GPR39.[1] It stimulates GLP-1 secretion in metabolic studies.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable