Fortfahren mit
SML2210
AubipyOMe
≥97% (NMR)
Synonym(e):
(SP-4-2)-dichloro(4,4′-dimethoxy-2,2′-bipyridine-kN1,kN1′)-Gold(1+), hexafluorophosphate(1-), [Au(4,4′-dimethoxy-2,2′-bipyridine)Cl2][PF6]
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 5 mg | Warenkorb auf Verfügbarkeit prüfen | € 90,70 | |
| 25 mg | Warenkorb auf Verfügbarkeit prüfen | € 369,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C12H12AuCl2N2O2 · PF6
CAS-Nummer:
Molekulargewicht:
629.07
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (NMR)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenassay
≥97% (NMR)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[Cl-][Au+3]1([N]2=C(C=C(C=C2)OC)C3=[N]1C=CC(OC)=C3)[Cl-].F[P-](F)(F)(F)(F)F
Biochem/physiol Actions
AubipyOMe is a potent inhibitor of tartrate resistant acid phosphatase (TRAP/ACP5), a metalloenzyme expressed in activated osteoclasts and in macrophages. AubipyOMe exhibited IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b and inhibited TRAP activity in murine macrophage and human lung tissue extracts.
Tartrate resistant acid phosphatase (TRAP/ACP5) inhibitor
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| assay ≥97% (NMR) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥95.0% (H-NMR) |
| form powder | form powder | form powder | form crystals |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility - |
| color white to beige | color light yellow to dark yellow | color white to beige | color - |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Carian E Boorsma et al.
Scientific reports, 7(1), 12570-12570 (2017-10-05)
The enzyme tartrate resistant acid phosphatase (TRAP, two isoforms 5a and 5b) is highly expressed in alveolar macrophages, but its function there is unclear and potent selective inhibitors of TRAP are required to assess functional aspects of the protein. We
Shujun Yang et al.
Molecular medicine (Cambridge, Mass.), 30(1), 89-89 (2024-06-16)
Myocardial infarction (MI) leads to enhanced activity of cardiac fibroblasts (CFs) and abnormal deposition of extracellular matrix proteins, resulting in cardiac fibrosis. Tartrate-resistant acid phosphatase 5 (ACP5) has been shown to promote cell proliferation and phenotypic transition. However, it remains
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2210-5MG | 04061835507719 |
| SML2210-25MG | 04061835507702 |