S8817

SB 218795

>98% (HPLC)

• Synonym(e): (−)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide
• Empirische Formel (Hill-System): C₂₅H₂₀N₂O₃
• Molekulargewicht: 396.44
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278467
• MDL number: MFCD00951240

Eigenschaften

• Quality Segment: 100
• assay: >98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: soluble 40 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: COC(=O)[C@H](NC(=O)c1cc(nc2ccccc12)-c3ccccc3)c4ccccc4
• Gene Information: human ... TACR2(6865), TACR3(6870)

Beschreibung

Application

The pharmacodynamics profile of SB 218795 enables its use as a tool to study physiological and pathophysiological roles of NK-3 receptor in CNS-modulated behaviors.

Biochem/physiol Actions

Non-peptide NK₃ tachykinin receptor antagonist.

SB 218795 is a 2-phenyl-4-quinolinecarboxamides and a selective, reversible and competitive antagonist of human NK-3 receptor that effectively crosses the blood-brain barrier. It inhibits the NK-3 receptor-induced miosis or pupil constriction in conscious rabbits.^1,2

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)