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S7936
SB 205384
solid
Synonym(e):
4-Amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester
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Über diesen Artikel
Empirische Formel (Hill-System):
C17H18N2O3S
CAS-Nummer:
Molekulargewicht:
330.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
form
solid
color
off-white
solubility
DMSO: 18 mg/mL, H2O: insoluble
SMILES string
CC#CCOC(=O)c1c(C)nc2sc3CC(O)CCc3c2c1N
InChI
1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19)
InChI key
JDTZAGLGBRRCJT-UHFFFAOYSA-N
Application
SB 205384 was used to study GABA-gated currents in rat locus coeruleus neurons.6
Biochem/physiol Actions
GABAA receptor modulator selective for the α3β2γ2 subunit combination.
SB 205384 is a selective and positive allosteric modulator of non-benzodiazepine site of the GABAA receptor.3 It affects the extrasynaptic GABAA receptors in rat cortical neurons4 and enhances the GABAergic transmission onto pro-opiomelanocortin neurons in mice.5
Legal Information
Manufactured and sold under license from GlaxoSmithKline Pharmaceuticals
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Verwandter Inhalt
Product Information Sheet
Sung Kun Chun et al.
Journal of neurophysiology, 104(5), 2321-2328 (2010-09-17)
Adaptive changes in hypothalamic neural circuitry occur in response to alterations in nutritional status. This plasticity at hypothalamic synapses contributes to the control of food intake and body weight. Here we show that genetic ablation of leptin receptor gene expression
José Francisco Navarro et al.
Psicothema, 20(1), 144-147 (2008-01-22)
GABA-A receptors are involved in the control of aggressive behaviour. Various studies suggest a role for a1-containing GABA-A receptors in modulating aggression. However, the possible involvement of a3 subunit of GABA-A receptors has not been examined. In this study, we
H J Meadows et al.
British journal of pharmacology, 123(6), 1253-1259 (1998-04-29)
1. SB-205384, and its (+) enantiomer (+)-SB-205384 were tested for their modulatory effects on human GABA(A) receptor subunit combinations expressed in Xenopus oocytes by electrophysiological methods. 2. The slowing of the decay rate induced by SB-205384 on native GABA-activated currents
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S7936-25MG | 04061832274157 |
| S7936-5MG | 04061832093642 |