S6321

Suptopin-2

≥98% (HPLC), solid

• Synonym(e): 4-Hydroxy-3-[3-(4-hydroxy-3,5-dimethyoxyphenyl)-1-oxo-2-propenyl]-6-methyl-2H-pyran-2-one, Suppressor of Topoisomerase II Inhibition
• Empirische Formel (Hill-System): C₁₇H₁₆O₇
• CAS-Nummer: 331852-66-5
• Molekulargewicht: 332.30
• NACRES: NA.77
• PubChem Substance ID: 24724619
• UNSPSC Code: 12352202
• MDL number: MFCD00810236
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: 11 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1cc(\C=C\C(=O)C2=C(O)C=C(C)OC2=O)cc(OC)c1O
• InChI: 1S/C17H16O7/c1-9-6-12(19)15(17(21)24-9)11(18)5-4-10-7-13(22-2)16(20)14(8-10)23-3/h4-8,19-20H,1-3H3/b5-4+
• InChI key: NCXJIWTVFHYSKF-SNAWJCMRSA-N

Beschreibung

Application

Suptopin-2 may be used to study cell signaling leading to cell cycle arrest.

Biochem/physiol Actions

Suptopin-2 affects cell cycle progression and stability of microtubules. It induces cell cycle arrest by regulating the nucleocytoplasmic transport of cyclin B1.¹

Sutopin-2 is a suppressor of topoisomerase II inhibition. Reverses cell cycle arrest; bypass of checkpoint function. Has inherent fluorescence and a distinct advantage in identification of molecule targets; effective concentraion in the μM range.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable