S6319

Sertralin -hydrochlorid

≥98% (HPLC)

• Synonym(e): (1S,4S)-4-(3,4-Dichlor-phenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalinamin -hydrochlorid
• Empirische Formel (Hill-System): C₁₇H₁₇NCl₂ · HCl
• CAS-Nummer: 79559-97-0
• Molekulargewicht: 342.69
• MDL-Nummer: MFCD00895772
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278601
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +33 to +43°, c = 2.0 in methanol
• Lagerbedingungen: desiccated
• Farbe: white
• Löslichkeit: DMSO: >20 mg/mL
• SMILES String: ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
• InChI: 1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
• InChIKey: BLFQGGGGFNSJKA-XHXSRVRCSA-N
• Angaben zum Gen: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Beschreibung

Anwendung

The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus.[1] It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans.[2]

Biochem./physiol. Wirkung

Ein selektiver Serotonin-Wiederaufnahmehemmer, Antidepressivum

Sertraline suppresses platelet function and exhibits antiplatelet and endothelium protective functions. It relieves depression and improves the quality of life in patients with cardiovascular disorders.[3][4] It can also be prescribed to treat depression in Parkinson′s disease.[5]

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H373,H410
• P-Sätze: P260 - P264 - P270 - P273 - P301 + P312 - P314
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)