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S4570

Sulochrin

≥98% (HPLC), solid

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Über diesen Artikel

Empirische Formel (Hill-System):
C17H16O7
CAS-Nummer:
Molekulargewicht:
332.30
UNSPSC Code:
51111800
PubChem Substance ID:
MDL number:


assay

≥98% (HPLC)

form

solid

solubility

DMF: soluble, DMSO: soluble, ethanol: soluble, methanol: soluble

antibiotic activity spectrum

fungi

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

COC(=O)c1cc(O)cc(OC)c1C(=O)c2c(O)cc(C)cc2O

InChI

1S/C17H16O7/c1-8-4-11(19)15(12(20)5-8)16(21)14-10(17(22)24-3)6-9(18)7-13(14)23-2/h4-7,18-20H,1-3H3

InChI key

YJRLSCDUYLRBIZ-UHFFFAOYSA-N

Application

Sulochrin was used as standard in LC/ESI for quantification of analytes from moldy food samples.[1]

Biochem/physiol Actions

Antibiotic from Aspergillus and Penicillium sp. Fungal metabolite; VEGF inhibitor and anti-angiogenic that inhibits the VEGF-induced tube formation of human umbilical vein endothelial cells.
Sulochrin, a metabolite of Aspergillus terreus and Penicillium sp., has weak anti-bacterial and anti-fungal properties. It inhibits the degranulation of eosinophils induced by the platelet activating factor.[2][3]


Lagerklasse

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Sulochrin inhibits eosinophil degranulation.
H Ohashi et al.
The Journal of antibiotics, 50(11), 972-974 (1998-05-21)
H Ohashi et al.
Bioorganic & medicinal chemistry letters, 9(14), 1945-1948 (1999-08-18)
Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and
Atsumi Shimada et al.
Bioscience, biotechnology, and biochemistry, 67(2), 442-444 (2003-05-06)
A new plant growth regulator, hydroxysulochrin (1), together with sulochrin (2) was isolated from the culture filtrate of Aureobasidium sp. grown on a malt extract medium. The structures of 1 and 2 were established by spectroscopic methods. 1 and 2