S4451

Sal003

≥98% (HPLC)

• Synonym(e): (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide, 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
• Empirische Formel (Hill-System): C₁₈H₁₅Cl₄N₃OS
• CAS-Nummer: 1164470-53-4
• Molekulargewicht: 463.21
• NACRES: NA.77
• PubChem Substance ID: 329824543
• UNSPSC Code: 12352200
• MDL number: MFCD00361095
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: desiccated, protect from light

Eigenschaften

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated, protect from light
• color: white to off-white
• solubility: DMSO: ≥10 mg/mL
• compatibility: for use with Bio-Rad CFX96
• storage temp.: 2-8°C
• SMILES string: Clc1ccc(NC(=S)NC(NC(=O)\C=C\c2ccccc2)C(Cl)(Cl)Cl)cc1
• InChI: 1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+
• InChI key: TVNBASWNLOIQML-IZZDOVSWSA-N

Beschreibung

Application

Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.[1]

Biochem/physiol Actions

Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.[2][3]

Sal003 is a potent and cell-permeable eIF-2a phosphatase inhibitor.

Sicherheitshinweise

• pictograms: GHS09
• signalword: Warning
• hcodes: H410
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable