S1438

Sulindac sulfone

≥94% (HPLC), (solid or powder)

• Synonym(e): (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfonyl)benzylidene]indene-3-acetic acid
• Empirische Formel (Hill-System): C₂₀H₁₇FO₄S
• CAS-Nummer: 59864-04-9
• Molekulargewicht: 372.41
• NACRES: NA.77
• PubChem Substance ID: 24278693
• UNSPSC Code: 51111800
• MDL number: MFCD01317811
• Assay: ≥94% (HPLC)
• Form: (solid or powder)
• Quality level: 100

Eigenschaften

• Quality Level: 100
• assay: ≥94% (HPLC)
• form: (solid or powder)
• color: , Light Yellow to Dark Yellow
• solubility: DMSO: >25 mg/mL, ethanol: 3 mg/mL (warm), acetone: 5 mg (plus 0.1 ml)
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• SMILES string: CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C\c3ccc(cc3)S(C)(=O)=O
• InChI: 1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+
• InChI key: MVGSNCBCUWPVDA-RQZCQDPDSA-N

Beschreibung

Application

Human endothelial cells, HMEC-1 were treated with Sulindac sulfone and the effect on cell survival was studied by MTT assay.[1]

Biochem/physiol Actions

Metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. Inhibits the development and induces regression of premalignant adenomatous polyps.

Sulindac sulfone is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells^1,2 and reduces tumor burden in adenomatous polyposis patients.³

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Sulindac sulfone yields clear, light yellow to dark yellow solution in acetone at 50 mg/ml.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)