S0758

Sulfaphenazole

≥98%, CYP2C9 inhibitor, powder

• Synonym(e): 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
• Empirische Formel (Hill-System): C₁₅H₁₄N₄O₂S
• CAS-Nummer: 526-08-9
• Molekulargewicht: 314.36
• NACRES: NA.77
• PubChem Substance ID: 24278198
• UNSPSC Code: 12352204
• EC Number: 208-384-3
• MDL number: MFCD00057226

Eigenschaften

• Produktname: Sulfaphenazole, ≥98%
• Quality Segment: 100
• assay: ≥98%
• form: powder
• solubility: ethanol: 25 mg/mL, clear, colorless to yellow
• storage temp.: 2-8°C
• SMILES string: Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3
• InChI: 1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
• InChI key: QWCJHSGMANYXCW-UHFFFAOYSA-N
• Gene Information: human ... CYP2C18(1562), CYP2C19(1557), CYP2C9(1559)

Beschreibung

Application

Sulfaphenazole has been used as a positive control to inhibit cytochrome P450 2C9 (cyp2c9) to quantify Rhodiola rosea inhibition. It has also been used as cytochrome P450 2C9 (cyp2c9) inhibitor in endothelial cells and microsomal preparations.

Biochem/physiol Actions

Antibacterial. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Inhibits bradykinin-induced tPA release.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)