R2530

Ropinirol -hydrochlorid

≥98% (HPLC), D2 and D3 dopamine receptor agonist, powder

• Synonym(e): 4-[2-(Dipropylamino)-ethyl]-1,3-dihydro-2H-indol-2-on -hydrochlorid, SKF 101468 -hydrochlorid
• Empirische Formel (Hill-System): C₁₆H₂₄N₂O · HCl
• CAS-Nummer: 91374-20-8
• Molekulargewicht: 296.84
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824018
• NACRES: NA.77
• MDL number: MFCD01754173
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: Ropinirol -hydrochlorid, powder, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: light yellow
• solubility: H₂O: >10 mg/mL
• originator: GlaxoSmithKline
• SMILES string: Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12
• InChI: 1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
• InChI key: XDXHAEQXIBQUEZ-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), DRD3(1814), DRD4(1815)

Beschreibung

Biochem/physiol Actions

Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.

An agonist at the D₂ and D₃ dopamine receptor subtypes, binding with higher affinity to D₃ than to D₂ or D₄. It has negligible effect on D₁-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT₁, 5-HT₂, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.

Selective D₂ dopamine receptor agonist, antiparkinsonian

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H400
• pcodes: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves