P5514

Mepyramin -maleat (Salz)

• Synonym(e): N-(4-Methoxyphenyl)-methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethandiamin, Pyrilamin -maleat (Salz)
• Empirische Formel (Hill-System): C₁₇H₂₃N₃O · C₄H₄O₄
• CAS-Nummer: 59-33-6
• Molekulargewicht: 401.46
• NACRES: NA.77
• PubChem Substance ID: 24277797
• UNSPSC Code: 12352116
• EC Number: 200-422-7
• MDL number: MFCD00069333
• Form: powder

Eigenschaften

• form: powder
• Quality Segment: 100
• originator: Watson
• SMILES string: OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
• InChI: 1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: JXYWFNAQESKDNC-BTJKTKAUSA-N
• Gene Information: human ... HRH1(3269)

Beschreibung

Application

Pyrilamine maleate salt has been used:

• to treat Cassiopea sp. as H₁ receptor antagonist
• to intraperitoneally inject mice to prevent the release of endogenous histamine
• in membrane binding assay to determine the K_i values and in the comparative inhibitory concentration (IC₅₀) studies by whole-cell patch clamp technique

Biochem/physiol Actions

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves