P0026

Pilsicainide hydrochloride

≥98% (HPLC)

• Synonym(e): N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide hydrochloride, Pilzicainide hydrochloride, SUN 1165
• Empirische Formel (Hill-System): C₁₇H₂₄N₂O · xHCl
• CAS-Nummer: 88069-49-2
• Molekulargewicht: 272.39 (free base basis)
• NACRES: NA.77
• PubChem Substance ID: 329819981
• UNSPSC Code: 12352200
• MDL number: MFCD00903769
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: desiccated

Eigenschaften

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: deionized water: >5 mg/mL
• storage temp.: room temp
• SMILES string: Cl.Cc1cccc(C)c1NC(=O)CC23CCCN2CCC3
• InChI: 1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H
• InChI key: NZOSVDHCTCLGEB-UHFFFAOYSA-N

Beschreibung

Application

Pilsicainide hydrochloride has been used as a sodium channel blocker:

• to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
• to study its effects on Ca²⁺ release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
• to study its electrophysiological effects on the guinea pig atrium

Biochem/physiol Actions

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels.

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na⁺¹ channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(⁺) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable