Fortfahren mit
O9505
Orotidine
≥90% (HPLC)
Synonym(e):
Uridine-6-carboxylic acid
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Über diesen Artikel
Empirische Formel (Hill-System):
C10H12N2O8
CAS-Nummer:
Molekulargewicht:
288.21
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
assay
≥90% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to light yellow
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C(=O)NC(=O)C=C2C(O)=O
InChI
1S/C10H12N2O8/c13-2-4-6(15)7(16)8(20-4)12-3(9(17)18)1-5(14)11-10(12)19/h1,4,6-8,13,15-16H,2H2,(H,17,18)(H,11,14,19)/t4-,6-,7-,8-/m1/s1
InChI key
FKCRAVPPBFWEJD-XVFCMESISA-N
Application
Orotidine, a nucleoside found naturally in fungi, bacteria and plants, may be used as a reference for the determination of presence of orotidine in urine or plasma due to urea cycle-related (transamidation) metabolic deficiencies or diseases.
Lagerklasse
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Meena K Purohit et al.
Journal of medicinal chemistry, 55(22), 9988-9997 (2012-09-21)
Orotidine-5'-monophosphate decarboxylase (ODCase) is an interesting enzyme with an unusual catalytic activity and a potential drug target in Plasmodium falciparum, which causes malaria. ODCase has been shown to exhibit unusual and interesting interactions with a variety of nucleotide ligands. Cytidine-5'-monophosphate
M A Carducci et al.
In vivo (Athens, Greece), 12(3), 271-274 (1998-08-26)
Allopurinol induced pyrimidinuria is a sensitive and specific test that identifies the increased de novo pyrimidine mononucleotide biosynthesis accompanying ornithine trans carbamylase deficiency. We hypothesize that the increased de novo DNA synthesis characteristic of malignant tumors can be detected using
E Riudor et al.
Journal of inherited metabolic disease, 23(7), 662-668 (2000-12-16)
Measurement of urinary orotidine and orotic acid after an oral allopurinol challenge is an important diagnostic test for ornithine carbamoyltransferase deficiency that is sometimes used in infants (< 1 year of age), although there is little information on normal test