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N161
NPC-15437 dihydrochloride hydrate
≥97% (NMR), powder
Synonym(e):
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide dihydrochloride hydrate
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Über diesen Artikel
Empirische Formel (Hill-System):
C25H50N4O2 · 2HCl · xH2O
CAS-Nummer:
Molekulargewicht:
511.61 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (NMR)
Form:
powder
Storage condition:
desiccated
assay
≥97% (NMR)
form
powder
storage condition
desiccated
color
white
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
InChI
1S/C25H50N4O2.2ClH/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26;;/h22-23H,2-21,26-27H2,1H3,(H,28,31);2*1H/t22?,23-;;/m0../s1
InChI key
RISSBZWRJRRXTD-OLBPYZPGSA-N
Application
NPC-15437 dihydrochloride hydrate has been used as a protein kinase C (PKC) inhibitor:
- to test its blocking effect on nicotine-seeking behavior in mice in drug-paired cues[1]
- along with cocaine to test its effect on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in mice[2]
- to study its effect on PKC signaling in object recognition memory studies[3]
Biochem/physiol Actions
NPC 15437 is also reported to be a P-glycoprotein (Pgp) modulator.[4]
Selective protein kinase C inhibitor.
Features and Benefits
This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Lagerklasse
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ainhoa Plaza-Zabala et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(9), 1724-1736 (2013-03-23)
Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin system in the reinstatement of nicotine-seeking behavior induced by nicotine-associated cues. Pretreatment with the hypocretin receptor-1 antagonist SB334867, but not
J P Sullivan et al.
Molecular pharmacology, 41(1), 38-44 (1992-01-01)
NPC 15437 is a prototype member of a new class of synthetically derived protein kinase C (PKC) inhibitors. PKC activity and binding of phorbol ester to the enzyme were inhibited by NPC 15437, with IC50 values of 19 +/- 2
E C Sha et al.
Investigational new drugs, 13(4), 285-294 (1996-01-01)
We assessed the effect of the protein kinase C inhibitor 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanami de (NPC 15437) on the action of anthracyclines, epipodophyllotoxins and vinca alkaloids in P-glycoprotein (Pgp)-expressing CH(R)C5 hamster ovary and MCF-7/Adria(R) human breast cancer cells. Flow microfluorimetry revealed that treatment
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N161-5MG | 04061832449029 |
| N161-25MG | 04061832272566 |