N1016

Nimesulid

• Synonym(e): N-(4-Nitro-2-phenoxyphenyl)-methansulfonamid
• Empirische Formel (Hill-System): C₁₃H₁₂N₂O₅S
• CAS-Nummer: 51803-78-2
• Molekulargewicht: 308.31
• NACRES: NA.77
• PubChem Substance ID: 24278583
• UNSPSC Code: 12352200
• EC Number: 257-431-4
• MDL number: MFCD00079470
• Assay: ≥98% (TLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• biological source: synthetic (organic)
• assay: ≥98% (TLC)
• form: powder
• solubility: ethanol: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O
• InChI: 1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
• InChI key: HYWYRSMBCFDLJT-UHFFFAOYSA-N
• Gene Information: human ... ALB(213), PTGS1(5742), PTGS2(5743)

Beschreibung

General description

Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) belongs to the sulfonanilide class.

Application

Nimesulide has been used as a component in the reaction mixture to determine the activity of cyclooxygenase (COX) in spleen of chickens.

Biochem/physiol Actions

Sehr selektiver Cyclooxygenase-2-Hemmer.

Nimesulide can be used as a substitute to other nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain and inflammation of osteoarthritis for a short period. It can perform anti-inflammatory, analgesic and antipyretic activities.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves