N0165

Nisoldipine

≥98% (HPLC)

• Synonym(e): (±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester, Sular
• Empirische Formel (Hill-System): C₂₀H₂₄N₂O₆
• CAS-Nummer: 63675-72-9
• Molekulargewicht: 388.41
• EG-Nummer: 264-407-7
• MDL-Nummer: MFCD00478055
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329818405
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: yellow
• Löslichkeit: DMSO: >10 mg/mL
• Ersteller: Bayer
• Lagertemp.: room temp
• SMILES String: COC(=O)C1=C(C)NC(C)=C(C1c2ccccc2[N+]([O-])=O)C(=O)OCC(C)C
• InChI: 1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
• InChIKey: VKQFCGNPDRICFG-UHFFFAOYSA-N
• Angaben zum Gen: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

Beschreibung

Anwendung

Nisoldipine has been used:

• as a hit-antagonist to study its effects on oxytocin (OT)-induced myometrial Ca²⁺-mobilization and its potency to dampen uterine myometrial contractions [1]
• as a calcium channel blocker to study its effects on cell viability in a human hepatic cancer HepG2 and rat renal epithelial NRK52E cell line [2]
• as a component of the external IK1 recording solution to study the action potential in human pluripotent stem cell−derived cardiomyocytes (hiPS-CMs)[3]

Biochem./physiol. Wirkung

L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.

Leistungsmerkmale und Vorteile

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable