M5820

M344

≥98% (HPLC), HDAC inhibitor, powder

• Synonym(e): 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide
• Empirische Formel (Hill-System): C₁₆H₂₅N₃O₃
• CAS-Nummer: 251456-60-7
• Molekulargewicht: 307.39
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818022
• NACRES: NA.77
• MDL number: MFCD03453554
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Eigenschaften

• Produktname: M344, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN(C)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO
• InChI: 1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
• InChI key: MXWDSZWTBOCWBK-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

M344 is a HDAC inhibitor and subtype selective for HDAC6 over HDAC1.

M344 is a HDAC inhibitor; subtype selective for HDAC6 over HDAC1. M344 inhibits HDAC (IC₅₀ = 100 nM) and also inhibits hyperacetylation of histone H4, terminal cell differentiation, transcription (γ-globin), and tumor cell death.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable