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M5005

Mangan(II)-chlorid Tetrahydrat

BioReagent, suitable for insect cell culture

Synonym(e):

Manganese chloride hydrate, Manganese chloride tetrahydrate, MnCl2.4H2O

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PackungsgrößeSKUVerfügbarkeitPreis
100 g
Warenkorb auf Verfügbarkeit prüfen
€ 47,70
500 g
Warenkorb auf Verfügbarkeit prüfen
€ 112,00

Über diesen Artikel

Lineare Formel:
MnCl2 · 4H2O
CAS-Nummer:
Molekulargewicht:
197.91
NACRES:
NA.28
PubChem Substance ID:
UNSPSC Code:
12352207
EC Number:
231-869-6
MDL number:
Assay:
≥99% (by AgNO3, titration)

€ 47,70


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product line

BioReagent

Quality Level

assay

≥99% (by AgNO3, titration)

technique(s)

cell culture | insect: suitable

mp

58 °C (lit.)

SMILES string

Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]

InChI

1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2

InChI key

CNFDGXZLMLFIJV-UHFFFAOYSA-L

Application

Manganese(II) chloride tetrahydrate has been used:
  • as trace element in the fungal complete medium
  • as a supplement in the culture medium for cochlear organotypic culture[1][2]
  • to determine its in vivo antiviral activity against herpes simplex virus-1 (HSV-1), vesicular stomatitis virus (VSV) and vaccinia virus in mice

Biochem/physiol Actions

Manganese is an essential and one of the abundant metal in the tissues of mammals. It plays a key role in the physiological process like development, neuronal function, immune regulation, reproduction, and antioxidant defences. It functions as a cofactor and regulates the activity of the enzymes like oxido-reductases, isomerases, transferases, ligases, lyases and hydrolases It is involved in the innate immunity against viruses.

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Dieser Artikel
22127963535M3634
assay

≥99% (by AgNO3, titration)

assay

≥98%, 98.0-101.0% (ACS specification)

assay

≥99.0% (KT)

assay

≥99%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

mp

58 °C (lit.)

mp

58 °C (lit.)

mp

58 °C (lit.)

mp

58 °C (lit.)

product line

BioReagent

product line

-

product line

BioUltra

product line

ReagentPlus®

technique(s)

cell culture | insect: suitable

technique(s)

-

technique(s)

-

technique(s)

-

redoxing cation, enzyme cofactor

-

-

-


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signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - STOT RE 2

target_organs

Brain

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

does not flash

flash_point_c

does not flash

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen



Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis
Ding X, et al.
Toxicology Letters, 310, 51-60 (2019)
manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Weilong Wang et al.
Toxicology letters, 279, 77-86 (2017-08-06)
Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including



Global Trade Item Number

SKUGTIN
M5005-500G04061834059363
M5005-100G04061834059356

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Is it okay to use this reagent on CHO-K1 cells?

    1 answer
    1. This product is use-tested in insect cell culture, not in mammalian cell culture. But it would be the best of the several Manganese(II) chloride tetrahydrate products listed.

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