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M4071

Sigma-Aldrich

MINK1 (1-320), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

B55, Hmink, MAP4K6, MGC21111, YSK2, ZC3, hMINKbeta

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.32

Rekombinant

expressed in baculovirus infected Sf9 cells

Qualitätsniveau

200

Produktlinie

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Spezifische Aktivität

16-22 nmol/min·mg

Mol-Gew.

~61 kDa

UniProt-Hinterlegungsnummer

Q8N4C8

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... MINK1(50488)

Allgemeine Beschreibung

Misshapen/NIKs-related kinase 1 (MINK1), also known as hMNIKβ or MINK is mapped to human chromosome 17p13.1. The gene codes for serine/threonine kinase, which is a member of the germinal center family of kinases (GCK) that are homologous to the yeast sterile 20 (Ste20) kinase family.

Biochem./physiol. Wirkung

Misshapen/NIKs-related kinase 1 (MINK1) plays a vital role in modulating various cellular process such as actin cytoskeleton rearrangement, cell matrix adhesion, cell-cell adhesion, cell morphology, and survival. It is also implicated in the cell motility and cell invasion. Kinase inactive mutant of MINK1 increased cell spreading, actin stress fiber formation, adhesion to extracellular matrix and inhibited cell motility and invasion. Thus, alteration in the MINK1 activity inhibits tumor development. MINK is activated after Ras induction via a method involving reactive oxygen species (ROS). This activated MINK triggers the activity of p38 stress-activated kinase via MAP3K (Mitogen-Activated Protein Kinase Kinase Kinase) 5/8 and MKK (mitogen-activated protein kinase kinase) 3/6, which leads to p53-independent induction of cyclin-dependent kinase inhibitor, p21WAF1/CIP1 and permanent cell cycle arrest. MINK1 has an essential role in abscission, which is a final stage of cytokinesis.

Physikalische Form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Rechtliche Hinweise

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.
Hu Y
The Journal of Biological Chemistry, 279(52), 54387-54397 (2004)
H Ozcelik
Cloning and Characterization of Expanded CAG-Repeat Containing Sequence(s): Identification of Candidate Breast Cancer Gene(s). (2003)
Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis.
Hyodo T
The Journal of Biological Chemistry, 287(30), 25019-25029 (2012)
Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.
Nicke B
Molecular Cell, 20(5), 673-685 (2005)

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