M182

MDL-12,330A hydrochloride

≥98% (HPLC), Adenylyl cyclase inhibitor, powder

• Synonym(e): cis-N-(2-Phenylcyclopentyl)-azacyclotridec-1-en-2-amine hydrochloride
• Empirische Formel (Hill-System): C₂₃H₃₆N₂ · HCl
• CAS-Nummer: 40297-09-4
• Molekulargewicht: 377.01
• UNSPSC Code: 41106305
• PubChem Substance ID: 24896696
• NACRES: NA.77
• MDL number: MFCD00210204
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: desiccated

Eigenschaften

• Produktname: MDL-12,330A hydrochloride, ≥98% (HPLC), powder
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl[H].C1CCCCCN=C(CCCCC1)N[C@H]2CCC[C@H]2c3ccccc3
• InChI: 1S/C23H36N2.ClH/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20;/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25);1H/t21-,22-;/m0./s1
• InChI key: CKOPQUCSDBVAQG-VROPFNGYSA-N

Beschreibung

Application

MDL-12,330A hydrochloride has been used as an inhibitor of adenylyl cyclase to block cyclic AMP signaling in mesenchymal stem/stromal cells (MSC).[1][2] It has also been used as an adenylyl cyclase blocker to test its effect on the locomotor activity based on tail suspension test (TST) in mice.[3]

Biochem/physiol Actions

Adenylyl cyclase inhibitor.

MDL-12,330A is a cycloalkyl lactamimide that acts as a voltage-gated potassium channel blocker (KV) leading to extension of action potential duration (APD) and favoring insulin secretion.[4] It also blocks calcium (Ca²⁺) entry.[4]

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)