LO1280

LOPAC^®1280

liquid

• Synonym(e): Library of Pharmacologically Active Compounds
• UNSPSC Code: 12352202
• Form: liquid
• Quality level: 100

Eigenschaften

• Produktname: LOPAC^®1280,
• form: liquid
• Quality Level: 100
• drug control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
• shipped in: dry ice
• storage temp.: −20°C

Beschreibung

General description

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO).

Application

LOPAC^®1280 has been used:

• in the screening of novel inhibitors for chemotaxis/ migration using Dictyostelium as a model
• to test the ability to modulate and to measure forskolin-stimulated cAMP levels in CHO-hCB₂ cells and to modulate ligand-induced receptor/β-arrestin interaction
• in screening of small molecules for activating bone morphogenetic protein (BMP) signaling
• in screening of compounds that plays a role in regulating subcellular localization of nitric oxide associated protein 1 (NOA1) protein

Features and Benefits

Collection of 1,280 Pharmacologically-Active Sigma Compounds

Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

• Apoptosis
• G Proteins & Cyclic Nucleotides
• Gene Regulation & Expression
• Ion Channels
• Lipid Signaling
• Multi-Drug Resistance
• Neurotransmission
• Phosphorylation

SDFile provided to construct a database containing:

• Structure
• Primary Name
• Secondary Name
• Pharmacological Activity
• Product Number
• Rack Position

To request a list of components, please visit sigma.com/LOPAC

Other Notes

For sale in the U.S. only. Customers outside of the U.S. should refer to product code LO3300.

Legal Information

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• pictograms: GHS06,GHS08,GHS05,GHS09
• signalword: Danger
• hcodes: H300 + H310 + H330,H314,H317,H334,H340,H350,H360FD,H362,H371,H373,H410
• pcodes: P263 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• flash_point_f: 188.6 °F - closed cup
• flash_point_c: 87 °C - closed cup
• wgk: WGK 3