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L6668

Sigma-Aldrich

Lercanidipine -hydrochlorid

≥98% (HPLC), powder, dihydropyridine calcium-channel blocker

Synonym(e):

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester 3,5-pyridinedicarboxylic acid hydrochloride

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About This Item

Empirische Formel (Hill-System):
C36H41N3O6 · HCl
CAS-Nummer:
132866-11-6
Molekulargewicht:
648.19
MDL-Nummer:
MFCD07773089
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24724527
NACRES:
NA.77

product name

Lercanidipine -hydrochlorid, ≥98% (HPLC)

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated
protect from light

Farbe

yellow

Ersteller

Forest Labs

Lagertemp.

2-8°C

SMILES String

O=C(OC)C1=C(C)NC(C)=C(C(OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)=O)C1C4=CC([N+]([O-])=O)=CC=C4.Cl

InChI

1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H

InChIKey

WMFYOYKPJLRMJI-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Lercanidipine hydrochloride is a L-type (Cav1.2b) vascular channel antagonist; L-type (Cav1.2a) cardiac channel agonist voltage-dependent and highly lipophylic compound, which exhibits a slower onset and longer duration of action than other calcium channel antagonists; an antihypertensive agent in patients with mild-to-moderate hypertension; more vasoselective than lacidipine and amlodipine.

Leistungsmerkmale und Vorteile

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Ketoprofen ≥98% (TLC)

Sigma-Aldrich

K1751

Ketoprofen

Huifeng Xu et al.
Gene, 500(2), 207-210 (2012-04-17)
To determine whether the antihypertensive and vascular protective effects of short-term treatment with lercanidipine, a calcium channel blocker, are modulated by the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism. In a self-controlled study, a total of 143 essential hypertensive patients, all permanent
Keguang Chen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 899, 1-7 (2012-05-25)
We aim to develop a rapid, simple, sensitive and specific LC-MS/MS method for the simultaneous quantification of lercanidipine, benazepril and benazeprilat in plasma. It is performed on the Agilent 6410 LC-MS/MS under the multiple-reaction monitoring (MRM) mode with electrospray ionization.
Jwu-Lai Yeh et al.
Atherosclerosis, 226(2), 364-372 (2013-01-08)
Inflammation is an important molecular basis of atherosclerosis. Recent studies have shown that dihydropyridine calcium channel blockers (CCBs) can exert potent anti-inflammatory effects in models of vascular dysfunction. The purpose of the present study was to evaluate anti-inflammatory effects and
Covadonga Álvarez et al.
European journal of clinical pharmacology, 68(7), 1043-1047 (2012-02-02)
The aim of this study was to compare the systemic exposure of lercanidipine (Zanidip) after oral administration in the fasted state and 15 min before food intake (meals) to investigate if the recommendations in the Summary of Product Characteristics (SPC)
Yuezhang Chen et al.
Molecular medicine reports, 16(4), 4545-4552 (2017-08-30)
Previous studies have demonstrated that lercanidipine, a calcium channel blocker, may protect against cardiac hypertrophy; however, the underlying mechanisms remain unclear. In the present study, the effects of lercanidipine on hypertrophy and the mechanisms involved were investigated. Cardiomyocytes isolated from
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