L1920

LY255283

≥98% (HPLC), powder

• Synonym(e): 1-(5-Ethyl-2-hydroxy-4-(6-methyl-6-(1H-tetrazol-5-yl)heptyloxy)phenyl)ethanone
• Empirische Formel (Hill-System): C₁₉H₂₈N₄O₃
• CAS-Nummer: 117690-79-6
• Molekulargewicht: 360.45
• NACRES: NA.77
• PubChem Substance ID: 329817396
• UNSPSC Code: 12352204
• MDL number: MFCD00876422
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: off-white to light yellow
• solubility: DMSO: >20 mg/mL
• originator: Eli Lilly
• storage temp.: −20°C
• SMILES string: CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c2nnn[nH]2
• InChI: 1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)
• InChI key: WCGXJPFHTHQNJL-UHFFFAOYSA-N

Beschreibung

Application

LY255283, a competitive leukotriene B4 receptor antagonist, is used in leukotriene receptor research along with other selective leukotriene receptor agonists and antagonist to identify and differentiate the physiological and cell signaling effects of the leukotriene B4 receptor on processes such as paclitaxel resistance in MCF-7/DOX breast cancer cells, monocyte-derived dendritic cell chemotaxis, and 5-lipoxygenase activity and interleukin-8 production in human neutrophils.[1] LY255283 may be used to help verify that an observed process or cell event is leukotriene B4 receptor-dependent.[1]

Biochem/physiol Actions

LY255283 is a competitive leukotriene B₄ receptor antagonist, specific to the BLT2 receptor subtype.

LY255283 is a competitive leukotriene B₄ receptor antagonist, with an IC₅₀ of about 100 nM. It is somewhat selective for the BLT2 receptor, since IC₅₀ values at the BLT1 receptor are >10 μM. LY255283 reduces airway obstruction in animal models of asthma.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable