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I9529

Sigma-Aldrich

Interleukin-10/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution

Synonym(e):

IL-10:Fc (non-lytic)

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About This Item

MDL-Nummer:
MFCD03457244
UNSPSC-Code:
51111800
NACRES:
NA.32

Biologische Quelle

mouse

Qualitätsniveau

200

Rekombinant

expressed in CHO cells

Assay

>98% (SDS-PAGE)

Form

buffered aqueous solution

Mol-Gew.

98 kDa

Verpackung

pkg of 10 μg

Verunreinigungen

endotoxin, tested

UniProt-Hinterlegungsnummer

P18893

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

mouse ... Il10(16153)

Biochem./physiol. Wirkung

IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis. It is secreted by monocytes and lymphocytes. It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells.
Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain.

Sonstige Hinweise

Dimeric fusion protein consisting of mouse IL-10 fused to mutant mouse IgG2a Fc.

Physikalische Form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Maciej Pastuszczak et al.
Human immunology, 76(7), 469-472 (2015-06-24)
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. Increased production of IL-10 has been found in late syphilis, presumably creating favorable conditions for bacteria persistence. Single-nucleotide polymorphisms (SNPs) within the promoter of IL-10 gene have been found to influence IL-10
C Gérard et al.
The Journal of experimental medicine, 177(2), 547-550 (1993-02-01)
Because of its ability to efficiently inhibit in vitro cytokine production by activated macrophages, we hypothesized that interleukin (IL) 10 might be of particular interest in preventing endotoxin-induced toxicity. We therefore examined the effects of IL-10 administration before lipopolysaccharide (LPS)
Lucia Elena Alvarado-Arnez et al.
PloS one, 10(9), e0136282-e0136282 (2015-09-05)
Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine
Manal Mohamed Makhlouf et al.
Laboratory medicine, 45(3), 211-219 (2014-07-23)
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of antiplatelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Interleukin 4 (IL4) and interleukin 10 (IL10) are important immunoregulatory

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