Yes, this product is known to work with human cells. A relevant citation that may serve as a reference is the following: J Mol Cell Cardiol. 2011 Feb;50(2):346-56. doi: 10.1016/j.yjmcc.2010.09.001. Epub 2010 Sep 15. - "Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes" PMID: 20837021.
I5271
IL-1β mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(e):
IL-1β, Interleukin-1β, Lymphocyte activating factor
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5 μG
€ 402,00
5 X 5 μG
€ 1.400,00
€ 402,00
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Über diesen Artikel
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
≥97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
17.5 kDa (containing 153 amino acid residues)
Impurities:
≤0.1ng/mg
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Unterstützung erhaltenProduktname
Interleukin-1β from mouse, IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
≤0.010 ng/mL ED50
quality
endotoxin tested
mol wt
17.5 kDa (containing 153 amino acid residues)
packaging
pkg of 5X5 μg, pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤0.1ng/mg
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Il1b(16176)
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1 of 4
Dieser Artikel | |||
|---|---|---|---|
| assay ≥97% (SDS-PAGE) | assay ≥97% (SDS-PAGE) | assay ≥97% (SDS-PAGE) | assay ≥97% (SDS-PAGE) |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| biological source mouse | biological source mouse | biological source mouse | biological source rat |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
General description
Interleukin-1β (IL-1β) cytokine is generated by monocytes, dendritic cells, macrophages and keratinocytes. Pro-IL-1β, an IL-1β precursor undergoes proteolytic cleavage to produce its active form of 17 kDa.[1]
Application
Interleukin-1β from mouse has been used:
- as a proinflammatory agent,[2] to induce inflammatory signaling cascades mediated cellular damage[3]
- to study its effect on fetuin A-induced inflammatory response in podocyte[4]
- to check its effect on the expression of mitogen-activated protein kinase 4 using 3T3-L1 adipocytes[5]
Biochem/physiol Actions
Interleukin-1β (IL-1β) is a potent inflammatory cytokine,[1] and mediates inflammation through proinflammatory molecules: cyclooxygenase-2 (COX2) and nitric oxide.[6] IL-1β release is stimulated by injury and increased levels are observed in response to severe pain.[7] It has its main function in T-cell activation, antigen recognition and T-helper cell 17 cell development. IL-1β is also responsible for the formation of IL-17 and IL-22 by nature killer T (NKT) cells and NK cells. It is known to induce inflammation in psoriasis and rheumatoid arthritis.[1] IL-1β controls intercellular adhesion molecule-1 expression. It is significantly associated with bone damage and vascular injury.[8]
Physical form
Lyophilized from 0.2 μm filtered solution in 10mM Sodium Citrate, pH 4.0
Analysis Note
The biological activity is measured by the dose-dependent stimulation of murine D10G4.1 cells.
Other Notes
The two closely related agents, Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) bind to the same cell surface receptor, elicit nearly identical biological responses and yet share 25% homology in their amino acid sequence.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes
Rogers TB, et al.
Journal of Molecular and Cellular Cardiology, 50(2), 346-356 (2011)
Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3. 2-USP5 interactions in the pain pathway
Stemkowski PL, et al.
Molecular Pain, 13 (2017)
TNFalpha stimulates Map4k4 expression through TNFalpha receptor 1 signaling to cJUN and ATF2
Tesz GJ, et al.
The Journal of Biological Chemistry (2007)
TNFalpha stimulates Map4k4 expression through TNFalpha receptor 1 signaling to cJUN and ATF2
Tesz GJ, et al.
Test (2007)
Wuttichai Jaidee et al.
Journal of natural products, 82(2), 283-292 (2019-01-30)
Four new chalcones (1, 10, 13, and 14), a new flavanone, (9), a new amide (8), and 19 known compounds were acquired from Melodorum siamensis. The structures were established by NMR and MS data analyses. Compounds 1 (er 1.4:1) and
Artikel
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
Verwandter Inhalt
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Is the I5271 Sigma-Aldrich Interleukin-1β from mouse cross-reactive with human cells and suitable for use in treating human cells?
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