I3525

Interleukin-17A human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Synonym(e): CTLA-8, IL-17
• MDL-Nummer: MFCD01094096
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 100
• Rekombinant: expressed in E. coli
• Assay: ≥98% (SDS-PAGE)
• Form: lyophilized powder
• Wirksamkeit: ≤2.0 ng/mL ED₅₀
• Mol-Gew.: 31 kDa
• Verpackung: pkg of 50 μg
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: endotoxin, tested (endotoxin level is less than 0.1 ng per μg cytokine (1 EU/μg).)
• UniProt-Hinterlegungsnummer: Q16552
• Lagertemp.: −20°C
• Angaben zum Gen: human ... IL17A(3605)

Beschreibung

Biochem./physiol. Wirkung

IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

Physikalische Form

Lyophilized with no additives.

Hinweis zur Analyse

• The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells.
• Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)