Insulin-like growth factor II (IGF II) also refers as multiplication stimulating activity or MSA is a protein that is structurally similar to proinsulin. It is a potent mitogen for many cultured cells like mouse 3T3 cells, normal rat kidney cells, human or chicken fibroblasts and MCF-7 human breast carcinoma cells. IGF II possess mitogenic growth factor property and hence facilitates growth-promoting activity in embryonic development. Anti-Insulin-Like Growth Factor-II antibody can be used for neutralization assays. Goat anti-Insulin-Like Growth Factor-II antibody reacts specifically with recombinant mouse IGF-II. The product has also shown 25% (approx.) cross-reactivity with recombinant human IGF-II.
Immunogen
purified recombinant mouse insulin-like growth factor II, expressed in E. coli.
Anwendung
Anti-Insulin-Like Growth Factor-II antibody can be used in ELISA and western blotting.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
A completely serum-free assay method has been used to compare the mitogenic activities of polypeptide growth factors and estrogens with MCF-7 and T47D human breast cancer cells in culture. The lines were maintained in a viable, slowly dividing condition in
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