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I0157

Ibudilast

≥99% (HPLC), Phosphodiesterase IV inhibitor, solid

Synonym(e):

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404

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PackungsgrößeSKUVerfügbarkeitPreis
10 mg
Warenkorb auf Verfügbarkeit prüfen
€ 270,00
50 mg
Warenkorb auf Verfügbarkeit prüfen
€ 1.030,00

Über diesen Artikel

Empirische Formel (Hill-System):
C14 H18 N2 O
CAS-Nummer:
Molekulargewicht:
230.31
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Quality level:

€ 270,00


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Produktname

Ibudilast, ≥99% (HPLC), solid

Quality Level

assay

≥99% (HPLC)

form

solid

color

white

solubility

DMSO: soluble 28 mg/mL, H2O: soluble 4.5 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)C(=O)c1c(nn2ccccc12)C(C)C

InChI

1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3

InChI key

ZJVFLBOZORBYFE-UHFFFAOYSA-N

Gene Information

Biochem/physiol Actions

Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Dieser Artikel
SML2749A9227SML1902
form

solid

form

powder

form

solid

form

powder

assay

≥99% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: soluble 28 mg/mL, H2O: soluble 4.5 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: freely soluble 22 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white

color

white to beige

color

white to beige

color

white to beige


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Artikel

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Verwandter Inhalt


Primary neuroprotection: the Holy Grail of multiple sclerosis therapy.
Robert J Fox
Neurology, 74(13), 1018-1019 (2010-03-05)
F Barkhof et al.
Neurology, 74(13), 1033-1040 (2010-03-05)
Ibudilast is a phosphodiesterase inhibitor influencing inflammation and neurodegeneration in multiple sclerosis (MS). This study evaluated the safety, tolerability, and effects on MRI parameters of 2 different doses of ibudilast in relapsing forms of MS. In this multicenter, double-blind, phase
Masahiro Noguchi et al.
Biological & pharmaceutical bulletin, 32(11), 1924-1927 (2009-11-03)
Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal



Global Trade Item Number

SKUGTIN
I0157-10MG04061833271643
I0157-50MG04061833271650

Questions

  1. Hello! I need to know whether I can prepare the working solution of the Ibudilast powder by diluting it in DMSO and freezing for storage at -20C. Will the compound be not degraded or damaged after freezing?

    1 answer
    1. This product is soluble in DMSO at 28 mg/mL. The recommended storage temperature is 2-8°C
      Please see the product data sheet for more information:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/268/374/i0157dat.pdf

      However, solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. The end-user will need to be cautious about keeping the product at -20°C for long-term storage and determine the stability at such temperatures empirically as this is not tested internally.

      Please see the link below: https://www.chemicalbook.com/ChemicalProductProperty_EN_CB0145945.htm

      Helpful?

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