Four simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for simultaneous determination of salbutamol sulphate (SS), bromhexine hydrochloride (BH) and etofylline (ET) in pure and commercial formulations without any prior separation or purification. They were first
Farmaco (Societa chimica italiana : 1989), 49(12), 809-818 (1994-12-01)
Matrix properties and release behaviour of monolithic devices based on a water soluble polymer has been investigated. Polyethyleneoxides of different molecular weights have been used and different molecular weight fractions have been blended in order to tune the release mechanism.
[The mechanisms of action of etophylline-clofibrate in hyperlipidemia].
I Păduraru et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 97(1), 445-449 (1993-01-01)
Methods and findings in experimental and clinical pharmacology, 13(4), 289-299 (1991-05-01)
beta-HET (beta-Hydroxyethyltheophylline), the major metabolite of the antibronchospastic, antiasthmatic drug doxofylline was studied in several in vitro and in vivo trials to characterize its pharmaco-toxicological profile. When compared to the parent compound, beta-HET was found to be significantly less active.
Differentiation-based therapeutics are an underutilized but potentially a significant option for cancer treatment. The effect of methylxanthines on melanoma cell differentiation has been well documented. We report the in-vitro and in-vivo anticancer potential of a theophylline analogue, 7-(2-hydroxyethyl)theophylline (HET), on
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