The storage stability temperature for this product is validated at -20°C. However, the product is shipped at ambient temperature. Shipping routes are configured to minimize transit time. Freezer storage products that ship at ambient temperature are considered stable up to 2 weeks for transit time.
Fortfahren mit
H5388
Hyaluronsäure Natriumsalz aus rooster comb
avian glycosaminoglycan polysaccharide
Synonym(e):
Kaliumhyaluronat
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 100 mg | Warenkorb auf Verfügbarkeit prüfen | € 125,00 | |
| 250 mg | Warenkorb auf Verfügbarkeit prüfen | € 265,00 | |
| 1 g | Warenkorb auf Verfügbarkeit prüfen | € 664,00 |
Über diesen Artikel
CAS-Nummer:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25
MDL number:
Technischer Dienst
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Unterstützung erhaltenbiological source
chicken (rooster comb)
Quality Segment
form
powder
impurities
≤2% protein (Lowry)
color
white
solubility
water: ~5 g/L
cation traces
Na: 3-7%
storage temp.
−20°C
SMILES string
[Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
InChI
1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
InChI key
YWIVKILSMZOHHF-QJZPQSOGSA-N
Application
Aus Hahnenkämmen extrahiertes Hyaluronsäure-Natriumsalz wird wie folgt verwendet:
- als Bestandteil eines zweischichtigen Gelatinegerüsts
- als Instrument zur Freigabe von Gentamicin bei chirurgischen Eingriffen am linken Ohr von Meerschweinchen
- in Hyaluronsäure-Bindungsassays mit der humanen embryonalen Nierenzelllinie 293T
Biochem/physiol Actions
Hyaluronsäure ist ein Polysaccharid, das in der Haut, im Bindegewebe, im Glaskörper des Auges und in der Gelenkflüssigkeit vorhanden ist. Sie ist für die Gewebehydratisierung von großer Bedeutung und trägt zur posttraumatischen Regeneration der Haut sowie zur Wundheilung bei. Außer ihren dermatologischen und ophthalmologischen Anwendungen dient Hyaluronsäure auch als Instrument zur Arzneimittelverabreichung. Hyaluronsäure weist außerdem antioxidative und antiglykolytische Eigenschaften auf.
Hochmolekulares Polymer, das aus wiederholenden dimeren Glucuronsäure-Einheiten und N-Acetylglucosamin besteht, die den Kern komplexer, in der extrazellulären Matrix vorhandenen Proteoglycan-Aggregate bilden.
Other Notes
Für einen umfassenden Überblick über unser vielfältiges Angebot an Polysacchariden für Ihre Forschung empfehlen wir Ihnen den Besuch unserer Seite zur Kategorie Kohlenhydrate.
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Dieser Artikel | |||
|---|---|---|---|
| biological source chicken (rooster comb) | biological source bacterial (Streptococcus zooepidemicus) | biological source - | biological source - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level - |
| solubility water: ~5 g/L | solubility water: 20 mg/mL, clear, colorless | solubility water: 10 mg/mL | solubility - |
| form powder | form powder | form lyophilized | form - |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
| cation traces Na: 3-7% | cation traces - | cation traces - | cation traces - |
Lagerklasse
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Protokolle
To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.
Artikel
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Discover the role of carbohydrates in drug delivery, from solubility and stability improvement to advanced controlled-release systems.
Explore how carbohydrates function as excipients and carriers in drug delivery, with insights into mechanisms, case studies, and future trends.
Verwandter Inhalt
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H5388-100MG | 04061833799369 |
| H5388-250MG | 04061833799383 |
| H5388-1G | 04061833799376 |
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How long is the product (Hyaluronic Acid, Product # H5388) stable at room temperature?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Mol Wt of H5388 (CAS Number 9067-32-7) Please share the Sodium Hyaluronate (g quantity) I am looking for Mol.Wt 100-200 Kda
1 answer-
This product has not been tested to determine the molecular weight. However, historical information indicates a range of 1.6 - 2 MDa. Currently, there is no product available at a molecular weight of 100-200 kDa. Product H7630, from bovine vitreous humor, has historically demonstrated a molecular weight of approximately 300 kDa. Please see the link below to review this product:
https://www.sigmaaldrich.com/product/sigma/h7630Helpful?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the purity of Hyaluronic acid, Product H5388?
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Sigma does not perform purity testing on this product due to the variable molecular weight and degradation that may occur in native glycosaminoglycans. This product is tested for activity and protein content which provide information regarding impurities and suitability.
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What is the molecular weight of Hyaluronic acid, Product H5388?
1 answer-
Product No. H5388 is a linear heteropolysaccharide with repeating 3-O-(β-D-glucuronido)-N-acetyl-D-glucosamine units linked by β-(1-->4)) hexosaminidic bonds. The molecular weight of this subunit has not been determined, but could be calculated from the information above. Molecular weights of hyaluronic acids vary from 0.1-10 million, depending on the source. The hyaluronic acid from rooster comb is expected to have a molecular weight of 1-4 million.
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What is the solubility of Hyaluronic acid, Product H5388?
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For Sigma's analytical test, 15 mg of this product is dissolved in 5 mL of 0.3 M phosphate buffer, pH 5.35 at 25°C (i.e., 3 mg/mL).
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