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H168
R(+)-7-Hydroxy-DPAT hydrobromide
>98%, solid
Synonym(e):
R(+)-2-Dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, R(+)-7-Hydroxy(dipropylamino)tetralin hydrobromide
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Über diesen Artikel
Empirische Formel (Hill-System):
C16H25NO · HBr
CAS-Nummer:
Molekulargewicht:
328.29
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
>98%
form
solid
color
white
solubility
H2O: >100 mg/mL, ethanol: >56 mg/mL
SMILES string
Br.CCCN(CCC)C1CCc2ccc(O)cc2C1
InChI
1S/C16H25NO.BrH/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15;/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3;1H
InChI key
ODNDMTWHRYECKX-UHFFFAOYSA-N
Gene Information
human ... DRD3(1814)
Biochem/physiol Actions
Selective D3 dopamine receptor agonist; active enantiomer of (±)-7-hydroxy-DPAT.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Photosensitive
Lagerklasse
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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R J Baldessarini et al.
European journal of pharmacology, 239(1-3), 269-270 (1993-08-03)
Racemic 7-hydroxy-N,N-dipropylaminotetralin (7-OH-DPAT) shows greater affinity for limbic-selective dopamine D3 receptors than for more ubiquitous dopamine D2 receptors. R(+)-7-OH-DPAT was prepared and evaluated in radioreceptor assays using membranes of fibroblasts expressing the human dopamine D3 receptor as well as rat
Megan E Breuer et al.
European journal of pharmacology, 616(1-3), 134-140 (2009-06-25)
Treatment with pramipexole, a dopamine D(3)/D(2) receptor agonist, reduces depressive symptoms in patients suffering from Parkinson's disease. To test the putative antidepressant quality of pramipexole, its effects were assessed in one of the most attractive animal models of depression, the
John R Mantsch et al.
Pharmacology, biochemistry, and behavior, 97(2), 310-316 (2010-09-08)
Levo-tetrahydropalmatine (l-THP) is an alkaloid found in many traditional Chinese herbal preparations and has a unique pharmacological profile that includes dopamine receptor antagonism. Previously we demonstrated that l-THP attenuates fixed-ratio (FR) cocaine self-administration (SA) and cocaine-induced reinstatement in rats at