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G1043

Sigma-Aldrich

Guanfacin -hydrochlorid

≥98% (HPLC)

Synonym(e):

N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide

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About This Item

Empirische Formel (Hill-System):
C9H9Cl2N3O · HCl
CAS-Nummer:
29110-48-3
Molekulargewicht:
282.55
MDL-Nummer:
MFCD00798230
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278452
NACRES:
NA.77

Assay

≥98% (HPLC)

Farbe

white

Löslichkeit

H2O: soluble 12 mg/mL at 60 °C

Ersteller

Promius

SMILES String

Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl

InChI

1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H

InChIKey

DGFYECXYGUIODH-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Anwendung

Guanfacine hydrochloride has been used as an α2A adrenoceptor agonist to test its protective effect on hypobaric hypoxia (HH) and in rat brain to measure blood oxygenation level dependent (BOLD) response.

Biochem./physiol. Wirkung

Guanfacine stimulates the brain postsynaptic α2 adrenergic receptor (AR) and mediates the prefrontal cortical (PFC) neuronal regulation and strengthens their network. Guanfacine improves the density of neuronal dendrites and is useful in treating neuropsychiatric disorders. It modulates the synaptic and cytoskeletal proteins expression in prefrontal cortical (PFC) neurons and may improve hypobaric hypoxia (HH) induced PFC dysfunctions. Guanfacine enhances cognitive function and is recommended for attention deficit hyperactivity disorder (ADHD) therapy.
α-2 noradrenergic receptor agonist.

Leistungsmerkmale und Vorteile

This compound was developed by Promius. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Sigma-Aldrich

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