F3929

Anti-Follicle-Stimulating Hormone Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-FSHR
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00162296
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC (p)
• Citations: 8

Eigenschaften

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• availability: not available in Japan
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 7-14 μg/mL
• UniProt accession no.: P23945
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FSHR(2492) ; mouse ... Fshr(14309) ; rat ... Fshr(25449)

Beschreibung

General description

Follicle stimulating hormone receptor (FSHR) belongs to the G protein-coupled receptors family and is a glycoprotein. FSHR gene is mapped to human chromosome 2p16.3. FSHR comprises hydrophilic domain, hydrophobic membrane regions, C-terminal extracellular domain, and short intracellular domain.

Immunogen

synthetic peptide coresponding to the N-terminal extracellular domain of human follicle-stimulating hormone receptor, conjugated to KLH. The immunizing peptide has 24% identity and 29% similarity with the mouse gene.

Application

Anti-Follicle-Stimulating Hormone Receptor antibody produced in rabbit has also been used in immunohistochemistry in ovine and reproductive tissues. It has also been used in western blotting.[1]

Biochem/physiol Actions

Follicle stimulating hormone receptor (FSHR) is located on Sertoli cells of the testes and the granulosa cells of ovary. The pituitary glycoprotein hormone, FSH, binds to FSHR and regulates the function of gonads and overall fertility. In Sertoli cells, FSHR-mediated cell proliferation determines the spermatogenic output. In ovarian granulosa cells, FSHR signaling mediates follicular growth and maturation of oocytes. Polymorphisms in the FSHR is implicated in premature ovarian insufficiency.

Physical form

Solution in phosphate buffered saline containing 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable