D185

Diethylenetriamine/nitric oxide adduct

≥97% (NMR), solid

• Synonym(e): 2,2′-(Hydroxynitrosohydrazono)bis-ethanimine, DETA/NO
• Empirische Formel (Hill-System): C₄H₁₃N₅O₂
• CAS-Nummer: 146724-94-9
• Molekulargewicht: 163.18
• NACRES: NA.77
• PubChem Substance ID: 24893279
• UNSPSC Code: 12352200
• MDL number: MFCD00210194
• Assay: ≥97% (NMR)
• Form: solid
• Storage condition: desiccated, under inert gas

Eigenschaften

• assay: ≥97% (NMR)
• form: solid
• storage condition: desiccated, under inert gas
• color: off-white
• solubility: H₂O: >20 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: NCCN(CC[NH3+])N([O-])N=O
• InChI: 1S/C4H12N5O2/c5-1-3-8(4-2-6)9(11)7-10/h1-6H2/q-1/p+1
• InChI key: PAOXTYJXTPPVHU-UHFFFAOYSA-O

Beschreibung

Application

Diethylenetriamine/nitric oxide adduct has been used as nitric oxide (NO) donor:

• to evaluate the direct effects of NO on cell proliferation in ovine trophectoderm (oTr1) cells[1]
• to test its effects on recreating the growth inhibitory effect of NO without the presence of macrophages[2]
• to correlate the outflow function and outflow tract vessel diameter changes with other controls in porcine models[3]

Biochem/physiol Actions

Diethylenetriamine/nitric oxide adduct (DETA/NO) is a NONOate, which has the longest NO?generating half?life in vitro. Inhaled DETA/NO acts as a pulmonary vasodilator in animals and humans.[4] This NO donor releases nitric oxide in solution in a controlled manner.[2] DETA/NO is associated with protein downregulation, upregulation of p53 expression. It enhances p53 post-translational modifications and also downregulates Nanog and Oct4 mRNA.[5]

Disclaimer

Air sensitive

Sicherheitshinweise

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Lagerklasse: 5.2 - Organic peroxides and self-reacting hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves