C6352

CTAP

≥95%

• Empirische Formel (Hill-System): C₅₁H₆₉N₁₃O₁₁S₂
• CAS-Nummer: 103429-32-9
• Molekulargewicht: 1104.30
• NACRES: NA.32
• PubChem Substance ID: 329775120
• UNSPSC Code: 12352200
• MDL number: MFCD00671434

Eigenschaften

• InChI: 1S/C51H69N13O11S2/c1-26(65)39(42(53)68)62-49(75)41-51(3,4)77-76-25-38(61-43(69)33(52)21-28-11-6-5-7-12-28)47(73)59-36(22-29-16-18-31(67)19-17-29)45(71)60-37(23-30-24-57-34-14-9-8-13-32(30)34)46(72)58-35(15-10-20-56-50(54)55)44(70)63-40(27(2)66)48(74)64-41/h5-9,11-14,16-19,24,26-27,33,35-41,57,65-67H,10,15,20-23,25,52H2,1-4H3,(H2,53,68)(H,58,72)(H,59,73)(H,60,71)(H,61,69)(H,62,75)(H,63,70)(H,64,74)(H4,54,55,56)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1
• SMILES string: C[C@@H](O)[C@H](NC(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc5ccccc5)[C@@H](C)O)C(N)=O
• InChI key: OFMQLVRLOGHAJI-FGHAYEPSSA-N
• assay: ≥95%
• form: powder
• UniProt accession no.: Q62923
• storage temp.: −20°C
• Quality Level: 200
• Gene Information: rat ... Pnoc(25516)

Beschreibung

Application

CTAP has been used as a μ-opioid receptor (MOR) antagonist:

• to study the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitor isoleucine-proline-isoleucine (IPI) and vildagliptin in carrageenan-induced inflammation[1]
• to study the role of MOR in glutamate and gamma-aminobutyric acid (GABA) efflux during predator stress in rats[2]
• to determine the endogenous opioid peptide involved in blocking pain induced by activated gastrin-releasing peptide (Grp⁺) neurons[3]

Biochem/physiol Actions

CTAP is a peptide antagonist produced from somatostatin analogs.[4]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)