C3993

Carvedilol

≥98% (HPLC), β-adrenergic blocker, solid

• Synonym(e): 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol, BM-14190
• Empirische Formel (Hill-System): C₂₄H₂₆N₂O₄
• CAS-Nummer: 72956-09-3
• Molekulargewicht: 406.47
• UNSPSC Code: 12352200
• PubChem Substance ID: 329775050
• NACRES: NA.77
• MDL number: MFCD00864692
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Produktname: Carvedilol, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• originator: GlaxoSmithKline
• SMILES string: OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC
• InChI: 1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
• InChI key: OGHNVEJMJSYVRP-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRB1(153), ADRB2(154), ADRB3(155)

Beschreibung

Application

Carvedilol has been used:

• as a β blocker to determine its effect on hypoxia inducible factor (HIF)-mediated erythropoiesis under hypoxia in vivo
• as a βAR antagonist for inhibition of bARs
• as a β-blocker to examine airway mechanics in fungus-challenged mice

Biochem/physiol Actions

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity.

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS08,GHS09
• signalword: Warning
• hcodes: H373,H411
• pcodes: P260 - P273 - P314 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2 - STOT RE 2
• target_organs: Liver,spleen,Uterus (including cervix),Adrenal gland
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves