C2776

1-Cyan-4-dimethylaminopyridinium-Tetrafluoroborat

organic cyanylating reagent

• Synonym(e): CDAP
• Empirische Formel (Hill-System): C₈H₁₀BF₄N₃
• CAS-Nummer: 59016-56-7
• Molekulargewicht: 234.99
• UNSPSC Code: 12352108
• NACRES: NA.32
• PubChem Substance ID: 24892528
• MDL number: MFCD00011998
• Beilstein/REAXYS Number: 5685616

Eigenschaften

• Quality Segment: 300
• assay: ≥97.00% (TLC)
• form: powder
• mol wt: 234.99 g/mol
• greener alternative product characteristics: Waste Prevention; Designing Safer Chemicals; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• concentration: 90-100 % (w/w) (1-Cyano-4-dimethylammoniumpyridinium tetrafluoroborate)
• color: white to yellow
• solubility: acetonitrile: 49.00-51.00 mg/mL, clear to slightly hazy, colorless to yellow
• λmax: 298-302 nm (0.1 N HCl)
• fluorescence: (EmM at Lambda max 28.00 - 32.00)
• greener alternative category: Aligned
• storage temp.: −20°C
• SMILES string: [F-].FB(F)F.CN(C)c1cc[n+](cc1)C#N
• InChI: 1S/C8H10N3.BF3.FH/c1-10(2)8-3-5-11(7-9)6-4-8;2-1(3)4;/h3-6H,1-2H3;;1H/q+1;;/p-1
• InChI key: ONCRRSYBEJHQMM-UHFFFAOYSA-M

Beschreibung

General description

1-Cyano-4-dimethylaminopyridinium tetrafluoroborate is an organic cyanylating agent also termed CDAP. [1] It is a unique cystine-labeling reagent due to its reactive nature under acidic conditions. This feature provides CDAP an advantage over other sulfhydryl labeling agents, as it can avoid potential thiol-disulfide exchange.[2]

We are committed to bringingyou greener alternative products, which adhere to one or more of the 12Principles of Greener Chemistry. 1-Cyano-4-DimethylaminopyridineTetrafluoroborate (CDAP) is a safer alternative to cyanogen bromide (CNBr) foractivating soluble polysaccharides in vaccine development. It operates at lowerpH levels, reducing toxicity and side reactions. CDAP enables quick activationfor protein-polysaccharide conjugate vaccines, bioconjugation, and drugdelivery, promoting sustainable practices in biochemistry and pharmaceuticals. Click here for more information.

Application

1-Cyano-4-dimethylaminopyridinium (CDAP) has been used in the synthesis of conjugate vaccines as a cyanylating agent.[3] Activation of cellulose dialysis membrane for immunosensor applications used CDAP as an activation agent.[4]

Features and Benefits

When compared to Cyanogen Bromide (CNBr), a similar reagent, CDAP is:

• Easier to use.[1]
• Can operate at lower pH levels.[1]
• Fewer side reactions.[1]
• Cyanogen Bromide is hazardous in nature.[5]

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves