C1997

CYM-5442

Name: CYM-5442
Brand: SIGMA
Price: 398 EUR

≥98% (HPLC)

Synonym(e):

2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol

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€ 398,00

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₃H₂₇N₃O₄

CAS-Nummer:

1094042-01-9

Molekulargewicht:

409.48

NACRES:

NA.77

PubChem Substance ID:

329774920

UNSPSC Code:

12352211

MDL number:

MFCD12912402

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InChI key

NUIKTBLZSPQGCP-UHFFFAOYSA-N

SMILES string

CCOc1ccc(cc1OCC)-c2nc(no2)-c3cccc4C(CCc34)NCCO

InChI

1S/C23H27N3O4/c1-3-28-20-11-8-15(14-21(20)29-4-2)23-25-22(26-30-23)18-7-5-6-17-16(18)9-10-19(17)24-12-13-27/h5-8,11,14,19,24,27H,3-4,9-10,12-13H2,1-2H3

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

Quality Level

100

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Dieser Artikel	SML2384	SML0501	SML2809
Sigma-Aldrich C1997 CYM-5442	Sigma-Aldrich SML2384 BAY 87-2243	Sigma-Aldrich SML0501 SB-590885	Sigma-Aldrich SML2809 WNK463
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form powder	form powder	form powder
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >5 mg/mL	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL (clear solution, warmed)	solubility DMSO: 2 mg/mL, clear

Biochem/physiol Actions

CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo through a hydrophobic pocket, separable from the orthosteric site of S1P binding that is headgroup dependent. This is a different site from those involved in the activities of other agonists such as FTY720 and SEW2871.

CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The S1P1 receptor-selective agonist CYM-5442 protects retinal ganglion cells in endothelin-1 induced retinal ganglion cell loss.

Román Blanco et al.

Experimental eye research, 164, 37-45 (2017-08-23)

We investigated the feasibility and efficacy of using a specific sphingosine 1-phosphate (S1P1) receptor agonist, CYM-5442, to slow or block retinal ganglion cell (RGC) loss in endothelin-1 (ET-1) induced RGC loss. A single intravitreal injection of ET-1 (20pmol/ul), a potent

Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2.

Alena Chumanevich et al.

Mediators of inflammation, 2016, 1503206-1503206 (2016-02-18)

Mast cells (MC) are present in most vascularized tissues around the vasculature likely exerting immunomodulatory functions. Endowed with diverse mediators, resident MC represent first-line fine-tuners of local microenvironment. Sphingosine-1-phosphate (S1P) functions as a pluripotent signaling sphingolipid metabolite in health and

Rapid changes in the ATG5-ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT).

Emily Crowley et al.

The FEBS journal, 287(22), 4917-4932 (2020-03-05)

Autophagy plays a role in several human diseases, but each of the current methods to measure autophagy has significant drawbacks. ATG5 and ATG16L1 are regulators necessary for autophagy; therefore, drugs that inhibit the interaction of these proteins may be therapeutically

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development.

Xiaochen Wang et al.

Immunity, 56(1), 58-77 (2022-12-16)

Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis (NASH)-an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear how such a low-grade, yet persistent, inflammation is sustained in the liver. Here, we show that the macrophage

The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus.

Léa M M Costes et al.

PloS one, 9(7), e102211-e102211 (2014-07-11)

Postoperative ileus is characterized by a transient impairment of the gastrointestinal motility after abdominal surgery. The intestinal inflammation, triggered by handling of the intestine, is the main factor responsible for the prolonged dysmotility of the gastrointestinal tract. Secondary lymphoid organs

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CYM-5442