B4750

N_α-Benzoyl-DL-arginin-2-naphthylamid -hydrochlorid

trypsin substrate

• Synonym(e): N_α-Benzoyl-DL-Arginin β-Naphthylamid -hydrochlorid, BANA
• Empirische Formel (Hill-System): C₂₃H₂₅N₅O₂ · HCl
• CAS-Nummer: 913-04-2
• Molekulargewicht: 439.94
• UNSPSC Code: 12352204
• NACRES: NA.32
• PubChem Substance ID: 24891699
• EC Number: 213-015-4
• Beilstein/REAXYS Number: 3823291
• MDL number: MFCD00038940

Eigenschaften

• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: DMF: 50 mg/mL, clear, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: Cl[H].NC(=N)NCCCC(NC(=O)c1ccccc1)C(=O)Nc2ccc3ccccc3c2
• InChI: 1S/C23H25N5O2.ClH/c24-23(25)26-14-6-11-20(28-21(29)17-8-2-1-3-9-17)22(30)27-19-13-12-16-7-4-5-10-18(16)15-19;/h1-5,7-10,12-13,15,20H,6,11,14H2,(H,27,30)(H,28,29)(H4,24,25,26);1H
• InChI key: BNGRKDJZQIGWQF-UHFFFAOYSA-N

Beschreibung

General description

A chromogenic substrate for trypsin.

Application

N_α-Benzoyl-DL-arginine β-naphthylamide hydrochloride has been used as a substrate in the BANA test to evaluate the inhibitory activity of stefin.[1] It has also been used as a substrate for the determination of Ki values of inhibitors toward trypsin.

Biochem/physiol Actions

N_α-Benzoyl-DL-arginine β-naphthylamide hydrochloride (BANA) helps to determine the activities of cathepsin B and papain. BANA test is also useful in identifying the number of periodontal sites with periodontal pathogens. Presence of volatile sulfur compounds (VSCs), synthesized by oral bacteria in dental plaque or tongue coating can be colorimetrically confirmed by their ability to hydrolyze N-benzoyl-DL-arginine-2-naphthylamide.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)