B4750

N_α-Benzoyl-DL-arginin-2-naphthylamid -hydrochlorid

Name: N<SUB>α</SUB>-Benzoyl-<SC>DL</SC>-arginin-2-naphthylamid -hydrochlorid
Brand: SIGMA
Price: 73.95 EUR

trypsin substrate

Synonym(e):

N_α-Benzoyl-DL-Arginin β-Naphthylamid -hydrochlorid, BANA

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500 MG

€ 73,95

1 G

€ 126,00

5 G

€ 356,15

€ 73,95

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₃H₂₅N₅O₂ · HCl

CAS-Nummer:

913-04-2

Molekulargewicht:

439.94

UNSPSC Code:

12352204

NACRES:

NA.32

PubChem Substance ID:

24891699

EC Number:

213-015-4

Beilstein/REAXYS Number:

3823291

MDL number:

MFCD00038940

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Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

DMF: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

Cl[H].NC(=N)NCCCC(NC(=O)c1ccccc1)C(=O)Nc2ccc3ccccc3c2

InChI

1S/C23H25N5O2.ClH/c24-23(25)26-14-6-11-20(28-21(29)17-8-2-1-3-9-17)22(30)27-19-13-12-16-7-4-5-10-18(16)15-19;/h1-5,7-10,12-13,15,20H,6,11,14H2,(H,27,30)(H,28,29)(H4,24,25,26);1H

InChI key

BNGRKDJZQIGWQF-UHFFFAOYSA-N

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Dieser Artikel	B4875	A2628	B3279
Sigma-Aldrich B4750 N_α-Benzoyl-DL-arginine β-naphthylamide hydrochloride	Sigma-Aldrich B4875 Nα-Benzoyl-DL-arginine 4-nitroanilide hydrochloride	Sigma-Aldrich A2628 L-Alanine β-naphthylamide	Sigma-Aldrich B3279 N_α-Benzoyl-L-arginine 4-nitroanilide hydrochloride
assay ≥98% (TLC)	assay ≥98%	assay ≥98% (TLC)	assay >98% (TLC)
solubility DMF: 50 mg/mL, clear, colorless to faintly yellow	solubility DMSO: 50 mg/mL (colorless to dark green-yellow to dark brown-yellow)	solubility ethanol: 50 mg/mL, clear to slightly hazy	solubility acetone: water (1:1): 40.00-51.00 mg/mL, clear, colorless to yellow
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C

General description

A chromogenic substrate for trypsin.

Application

N_α-Benzoyl-DL-arginine β-naphthylamide hydrochloride has been used as a substrate in the BANA test to evaluate the inhibitory activity of stefin.[1] It has also been used as a substrate for the determination of Ki values of inhibitors toward trypsin.

Biochem/physiol Actions

N_α-Benzoyl-DL-arginine β-naphthylamide hydrochloride (BANA) helps to determine the activities of cathepsin B and papain. BANA test is also useful in identifying the number of periodontal sites with periodontal pathogens. Presence of volatile sulfur compounds (VSCs), synthesized by oral bacteria in dental plaque or tongue coating can be colorimetrically confirmed by their ability to hydrolyze N-benzoyl-DL-arginine-2-naphthylamide.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Trypsin-like serine proteases in Lutzomyia longipalpis--expression, activity and possible modulation by Leishmania infantum chagasi.

Erich Loza Telleria et al.

PloS one, 5(5), e10697-e10697 (2010-05-27)

Midgut enzymatic activity is one of the obstacles that Leishmania must surpass to succeed in establishing infection. Trypsins are abundant digestive enzymes in most insects. We have previously described two trypsin cDNAs of L. longipalpis: one (Lltryp1) with a bloodmeal

Biochemical and biological properties of leukocyte intracellular inhibitors of proteinases

Macrophages and Lymphocytes, 15(1), 75-83 (1980)

A simple point of care test can indicate the need for periodontal therapy to reduce the risk for adverse pregnancy outcomes in mothers attending antenatal clinics.

Mervyn Sydney Turton et al.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 22(8), 740-746 (2017-06-01)

Although the association between periodontal disease (PD) and adverse pregnancy outcomes has gained recognition amongst antenatal healthcare workers, not much has changed in practice to address it. This prospective study tested the hypothesis that BANA (N-benzoyl-DL-arginine-2-naphthylamide), a diagnostic test for

Some thiocarbamoyl based novel anticathepsin agents.

Ravinder Kaur et al.

Bioorganic chemistry, 104, 104174-104174 (2020-09-16)

Cathepsins have emerged as important targets in various tissues degenerative disorders due to their involvement in degradation of extracellular matrices and endogenous protein turnover. Elevated cathepsins levels vis-à-vis decreased concentration of endogenous inhibitors has been reported at different diseased sites.

Kunitz-type protease inhibitors group B from Solanum palustre

Speransky A S, et al.

Biotechnology Journal, 2(11), 1417-1424 (2007)

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Global Trade Item Number

SKU	GTIN
B4750-1G	04061833433447
B4750-5G	04061832921341
B4750-500MG	04061832921334

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N_α-Benzoyl-DL-arginin-2-naphthylamid -hydrochlorid