A5845

N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin

≥95% (HPLC), powder

• Synonym(e): Ac-LEHD-AFC
• Empirische Formel (Hill-System): C₃₃H₃₈O₁₁N₇F₃
• Molekulargewicht: 765.69
• NACRES: NA.32
• PubChem Substance ID: 329770876
• UNSPSC Code: 12352209
• MDL number: MFCD01862610

Eigenschaften

• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: powder
• color: white
• solubility: DMSO/DMF: 20 mM
• storage temp.: −20°C
• SMILES string: CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2
• InChI: 1S/C33H38F3N7O11/c1-15(2)8-22(39-16(3)44)31(52)41-21(6-7-26(45)46)29(50)42-23(9-18-13-37-14-38-18)32(53)43-24(12-27(47)48)30(51)40-17-4-5-19-20(33(34,35)36)11-28(49)54-25(19)10-17/h4-5,10-11,13-15,21-24H,6-9,12H2,1-3H3,(H,37,38)(H,39,44)(H,40,51)(H,41,52)(H,42,50)(H,43,53)(H,45,46)(H,47,48)/t21-,22-,23-,24-/m0/s1
• InChI key: HULKIXRFKRCRHD-ZJZGAYNASA-N
• Gene Information: human ... CARD9(64170), CASP9(842) ; mouse ... CARD9(332579), CASP9(12371) ; rat ... CARD9(64171), CASP9(58918)

Beschreibung

General description

Amino acid derivatives of 7-amido-4-trifluoromethylcoumarin (AFC) are blue in fluorescence microscopy.

Application

N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin has been used to assay caspase 9 activity using a substrate-based fluorimetric detection assay[1]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)