487R-9

SMAD4 (MRQ-72) Rabbit Monoclonal Antibody

• Synonym(e): Mothers Against Decapentaplegic Homolog 4 Rabbit Monoclonal Antibody
• UNSPSC Code: 12352203
• Clone: MRQ-72, monoclonal
• Species reactivity: -
• Application: —
• Citations: 6

Eigenschaften

• biological source: rabbit
• Quality Segment: 500
• antibody product type: primary antibodies
• clone: MRQ-72, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• packaging: vial of 0.1 mL concentrate (487R-94), vial of 0.1 mL concentrate (487R-94-RUO) Research Use Only, vial of 0.5 mL concentrate (487R-(95), vial of 1.0 mL (concentrate (487R-96)), vial of 1.0 mL concentrate (487R-96-RUO) Research Use Only, vial of 1.0 mL pre-dilute (487R-97-RUO) Research Use Only, vial of 1.0 mL pre-dilute ready-to-use (487R-97), vial of 7.0 mL pre-dilute ready-to-use (487R-98), vial of 7.0 mL pre-dilute ready-to-use (487R-98-RUO) Research Use Only
• manufacturer/tradename: Cell Marque^®
• isotype: IgG
• control: pancreas
• visualization: cytoplasmic, nuclear

Beschreibung

General description

Mothers Against Decapentaplegic Homolog 4 (SMAD4) is a transcription factor that is involved in TGFβ signalling pathways and acts as a tumor suppressor[1]. SMAD4 is commonly expressed in a variety of cancers, including pancreatic ductal adenocarcinoma (PDA), colorectal carcinoma (CRC), hepatocellular carcinoma (HCC), and gastric carcinomas, as well as non-neoplastic liver, pancreas, and colon.[2] [3]However, a loss of expression has been observed in a subset of PDA, CRC, and gastric carcinomas due to a variety of mutations including nonsense, missense, deletions, and splice site changes.[4] [2]In contrast, SMAD4 is over-expressed in HCC compared to the weak expression that is exhibited in the non-neoplastic liver.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and format

Note: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD - MQ500

RUO - MQ100

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 2